Skin reactions severe
in % of patients taking were reported skin reactions to severe, which may be accompanied by fever and / or an increase in liver transaminases. Stevens-Johnson syndrome was reported rarely (<%). In the post-marketing period, toxic epidermal necrolysis has been recorded very rarely (<%). If you have any signs or symptoms of skin reactions to severe (rash severe course or rash accompanied by fever, general malaise, muscle pain or joint pain, blisters, oral lesions, conjunctivitis, hepatitis and / or eosinophilia) receiving should be discontinued immediately.
rash (all species) was observed in % of patients taking. Rash was mostly mild or moderate, and often observed during the first four weeks of treatment and decreased with continued % of cases, the rash was caused the cancellation of a combination of ritonavir.
Darunavir contains a sulfonamide group. Appointment in patients with allergy to sulfonamides should be done with caution. In clinical studies, ritonavir, the degree and frequency of eruptions were similar in patients with allergy to sulfonamides history without it.