Testosterone and its derivate are made synthetically pharmaceutically as drugs for many different treatments. Pharmaceutical research of anabolic steroid is not focused a lot on muscle grow in healthy individuals but only in some aging related diseases like sarcopenia – the loss of skeletal muscle mass and strength as a result of aging. Osteoporosis is one of the aging diseases that is also sometimes treated with anabolic steroids. In all these treatments, serious hormonal misbalance is highly possible, and a reaction of other, not targeted tissues. Some of the side effects using anabolic steroids can lead to liver conditions like peliosis hepatis – blood-filled cysts replacing healthy liver cells. This condition is often diagnosed late when it is already life threatening to treat liver failure present or intra-abdominal bleeding start.
Primobolan side effects include that of cardiovascular strain and negative cholesterol changes, which is a side effect shared among all anabolic steroids. This involves the reduction of HDL (the good cholesterol) and increases of LDL (the bad cholesterol). The result of such changes is an increased risk of arteriosclerosis, and the degree to which these changes occur for the worse are usually dose-dependent (with higher doses increasing the negative changes and the risks). Other factors that affect these negative cholesterol changes are: duration of use, and route of administration. In terms of the route of administration, oral anabolic steroids are known as being the worst for their negative impacts on cholesterol in comparison to injectable anabolic steroids. This is where oral anabolic steroids hold a negative reputation for exhibiting a far worse negative impact on cholesterol in comparison to injectable anabolic steroids. This is due to the fact that the liver is essentially the body’s cholesterol processing and production center, and increased hepatotoxicity as a result of oral anabolic steroid use is associated with negative cholesterol changes.