Anastrozole has been tested for reducing estrogens, including estradiol, in men.  Excess estradiol in men can cause benign prostatic hyperplasia , gynecomastia , and symptoms of hypogonadism . It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer.  Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen-- gynecomastia , emotional lability and water retention.  Study data suggest dosages of mg to 1 mg a day reduce serum estradiol by approximately 50% in men, which differs in postmenopausal women. 
Dear Dr Miller, myself and my wife we were trying to have baby since last 3 yrs but no success. Last month i went to doctor and had my FSH,LH,T and SA tests done. FSH – uIU/ml, LH – uIU/ml, T – ng/ml. Sperm count was M/ml. Doctor told me that LH and T are normal where as FSH is high. He suggested me to take clomid 25mg daily to increase my sperm production . After 1 month , i had done my SA tests again . i expected sperm count to increase but instead i found out that my sperm count has actually decreased to M/ml. Pls help me doctor
Objective: To investigate the effects of mesterolone on prostate in patients treated for aging male syndrome.
Methods: The cross-sectional study was conducted from June to September, 2009, at endocrinology and metabolism department of Yuzuncu Yil University, Van, Turkey, and comprised patients with symptoms of aging male syndrome and/or low testosterone. They were given mesterolone 50mg/day per oral for two months. Aging Male Symptoms and International Prostate Symptom Score questionaires and prostate-related quality of life scores were completed and prostate ultrasonography (USG) was performed before and after the treatment. Total testosterone, free testosterone, gonadotropins, estradiol, prolactin, sex-hormone binding globulin, as well as total and free prostate-specific antigen were also studied.
Results: Of the 34 patients in the study, 22(%) had their prostate volume increased, while 12(%) had it decreased. The change, however, was not statistically significant (p