Testim (testosterone) for Hypogonadism, Male: "I was prescribed Testim once in error and now again for a second time. The first time it had moderate effect on my t levels; unfortunately my prescription plan considers 2 tubes /day adequate. In addition, it is very difficult to apply, and difficult to bear on your skin. Goes on sticky and stays sticky; your clothes will stick to your body. The metal tubes make it difficult if not impossible to apply all of the gel. Worse, it is difficult to remove even the next day in the shower. I actually had to use dishwashing liquid."
After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .