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The annualized rate of the primary end point during treatment was % with warfarin (median time in the therapeutic range, %), as compared with % with high-dose edoxaban (hazard ratio, ; % confidence interval [CI], to ; P< for noninferiority) and % with low-dose edoxaban (hazard ratio, ; % CI, to ; P= for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, ; % CI, to ; P=) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, ; % CI, to ; P=). The annualized rate of major bleeding was % with warfarin versus % with high-dose edoxaban (hazard ratio, ; 95% CI, to ; P<) and % with low-dose edoxaban (hazard ratio, ; 95% CI, to ; P<). The corresponding annualized rates of death from cardiovascular causes were % versus % (hazard ratio, ; 95% CI, to ; P=), and % (hazard ratio, ; 95% CI, to ; P=), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were % versus % (hazard ratio, ; 95% CI, to ; P=), and % (hazard ratio, ; 95% CI, to ; P=).

There are a lot of Dragon Ball games, and most of them are nothing to write home about. I recall the announcement of Dragon Ball Z: Budokai . At that time, all we had was Dragon Ball GT: Final Bout , a real clunker of a shitfest that was barely playable, but that I hunted down regardless just to get a taste of something, anything localized. It's funny to look back now and see how far the series has come and how the popularity of its localization (thanks, Funimation!) drove the games forward and brought us some really fun, if not always good or polished titles to play.

Dragon Ball Z GT covers all the editions of "Dragon Ball" and the latest fan sites, as well as official sites. When there's a new post, a push notification can let you know about it right away. The app combs social media sites, as well as video and other content areas, looking for anything related to the series and lets you know about it right away. You can also use Dragon Ball Z GT to comment on anything that's pushed to your iPhone and iPad, sharing your thoughts with others. The app lets you create a log-in on the publisher's site, too.

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